Users can query the the substrates database using one of the three methods:

Using Accession IDs -such as the CASVM Accession IDs or UniProt IDs. Every substrate entry in CASVM will be assigned with an accession ID (beginning with "CS" and followed by a 4-digit code).

Or using keywords (synonyms, common protein names, gene names) such as PARP-1 or Bax:

Or using sequence similarity (BLASTP algorithm):

Upon form submission, the results of the search will be displayed as shown below. Users can click on the CASVM accession ID of each retrieved record to view the details of the particular substrate:

Below shows the screenshot of a webpage displaying the details of a substrate record in the database:

Explanantion of the fields in the table output:

CASVM Accession ID:
The assigned accession number for the particular substrate.

Substrate Name(s):
Name of substrate. Some substrates may have multiple names.

Organism Type:
Organism source of substrate which was used in the experiments describing cleavage.

UniProt ID:
The UniProt Accession ID.

Cleavage Site(s):
Experimentally determined tetrapeptide sequence(s) which is(are) recognized by caspases. Usually the last residue is an aspartate. The number within parentheses indicate the position of the first residue (P4) of the tetrapeptide sequence in the substrate protein.

Cleavage Effect(s):
The consequences of cleavage of substrates on cellular physiology and function.

Caspase(s) Involved:
Indicates the caspase or caspases responsible for substrate cleavage.

Comments:
Addtional comments/information on the substrate.

Sequence:
users can download the sequence in FASTA format.

References:
Primary references on the experimental work showing substrate cleavage.