CASVM (version 1.0) is a web
server for predicting caspase cleavage sites on protein sequences
based on the SVM algorithms developed by Wee
et al. CASVM is updated regularly with newly discovered caspase
substrates which can be retrieved from the substrates
database. Caspases (for cysteine aspartate proteases)
belong to a family of cysteine proteases that serve as important
effectors of apoptosis, inflammation and other critical cellular
processes. These proteases are unique among mammalian proteases
as they cleave substrates after an aspartate residue at sites bearing
signature tetrapeptide motifs (learn
more about caspases).
(A simplified model of caspase-dependent apoptosis.
From Hengartner, 2000)
Please cite the following articles for results obtained
from this server:
- Lawrence JK Wee, Tin Wee Tan and Shoba Ranganathan,
SVM-based prediction of caspase substrate cleavage sites, BMC
Bioinformatics 2006, 7(Suppl 5):S14.
- Lawrence JK Wee, Tin Wee Tan and Shoba Ranganathan,
CASVM: Server for SVM-based prediction of caspase substrate cleavage
sites, unpublished results.
Funding support from the Department
of Biochemistry, Yong Loo Lin School of Medicine, National University
of Singapore to LJK Wee (lawrence@bic.nus.edu.sg) is acknowledged.
Server was lasted updated on 31 Jan 2007.
|
